Endocrine Abstracts

Case presentation: This detailed case report delves into the complex clinical trajectory of a 37-year-old Afro-Caribbean woman hailing from Zimbabwe, who presented with a diverse array of symptoms. Among these were diarrhea, tremor, anxiety, abdominal distension, amenorrhea and a staggering unintentional weight loss of 1 kg over the past year. Notably, her medical history features a previous open left-sided salpingectomy undertaken for a ruptured ectopic pregnancy. The persist...

The objective of the study was to assess the effect of intra-muscular testosterone on glycemic control, metabolic parameters and hypogonadal symptoms in men with hypogonadism and poorly controlled type 2 diabetes. This is a randomised double-blinded placebo-controlled add-on trial of intramuscular-testosterone undecanoate(Nebido®) administered every 12 weeks in 65 hypogonadal men with poorly-controlled diabetes. Phase-1 patients were randomly assigned to either...

Objective: The objective of the study was to assess the effect of intra-muscular testosterone on body composition in men with hypogonadism and poorly controlled type 2 diabetes.Research design and methods: This is a randomised double-blinded placebo-controlled add-on trial of intramuscular testosterone undecanoate administered every 12 weeks in 65 hypogonadal men with poorly-controlled diabetes. Phase 1 patients were randomly assigned to either treatment...

Introduction: We undertook an audit evaluating the glycaemic management of patients on steroids. This audit is based on the Joint British Diabetes Societies guideline on Management of Hyperglycaemia and Steroid (Glucocorticoid) Therapy, 2014.Method: The audit was conducted prospectively over a period of 5 days. All patients on steroids greater than 5 mg of Prednisolone, or an equivalent dose of alternative synthetic gluc...

Introduction: We undertook an audit evaluating the glycaemic management of patients on steroids. This audit is based on the Joint British Diabetes Societies guideline on Management of Hyperglycaemia and Steroid (Glucocorticoid) Therapy, 2014.Method: The audit was conducted prospectively over a period of 5 days. All patients on steroids greater than 5 mg of Prednisolone, or an equivalent dose of alternative synthetic gluc...

Background: Covid 19 infection has previously been reported to be associated with worsening of pre-existing and new onset diabetes mellitus1. However, the association of new onset autoimmune diabetes mellitus after Covid vaccination is not fully recognised in the literature.History: We report the case of a 58-year-old healthy woman who received a Covid 19 vaccination on 14th of Nov 2021. 2 weeks subsequently she was admitted with headache, blurred vision...

Diagnosis of Cushing’s syndrome is challenging in the absence of cardinal features. But still, they have the same metabolic risk due to the presence of biochemical hypercortisolism. A 35-year lady was referred to the tertiary care endocrine unit following an incidental finding of high cortisol levels while on treatment for covid in 2021. She also had some weight gain, slow healing of wounds, and easy bruising. She did not have any features of hyperandrogenism and hyperten...

Waterhouse–Friderichsen Syndrome is adrenal gland failure due to adrenal haemorrhage. It is an uncommon but usually life-threatening condition, which can be one of the serious complications of severe sepsis. Clinical manifestations of adrenal haemorrhage can vary widely depending on the degree and rate of haemorrhage. Adrenal haemorrhage may result from trauma, sepsis, anticoagulation medication, coagulopathy, autoimmune conditions, underlying tumour or idiopathic disease...

Introduction: We undertook a service development audit within our trust to review the Medical team’s knowledge on DKA and the management involved in treating these patients. The aim was to identify where there was a lack of knowledge in this area so we could provide teaching sessions on DKA and aim at the specific areas highlighted from the audit. We went on to deliver education sessions on DKA management and pinpointed the areas lacking from the pre audit. The education ...

Aims: To look at the demographics, biochemistry, treatments used, clinical characteristics associated with radioiodine (RI) treatment (including those with relapse) for thyrotoxicosis in our Endocrine clinic.Methods: Electronic records of all thyrotoxic patients between 2010 and 2012.Results: 144 patients, mean age 56 years (114 females)–106 Graves, 24 toxic adenoma (TA) and 14 multi nodular goitre (MNG). TPO antibody was posi...